Genetics Unzipped

026  The future is now: Curing HIV, advancing CRISPR therapies, predatory phages for superbug infections and advice for a healthy life

In this episode we’re reporting back from the Manova Global Health Summit, exploring the latest advances in health technology such as CRISPR-based gene therapies, infection-fighting viruses and a potential cure for HIV.  Plus veteran health columnist Jane Brody’s advice for a healthy life, and reflections on progress in cancer from US journalist and advocate Katie Couric.

 

 

025  When ‘Becky’ met Bateson: Edith Rebecca Saunders, the mother of British plant genetics

The history of genetics has a few famous partnerships – such as James Watson and Francis Crick or Francois Jacob and Jacques Monod.  But there’s one pair without whom this podcast wouldn’t exist at all, and that’s Edith Rebecca Saunders and William Bateson, who founded The Genetics Society one hundred years ago.

 

 

024 Exploring the Poop-ome, from the microbiome to metagenomic

We’re getting our hands dirty by delving into the poop-ome – the trillions of bacteria that live inside our guts and make up what’s known as the microbiome.  Rather than simply being a bunch of bugs, the microbiome is now believed to play a role in virtually every aspect of health and disease.  But what are they up to?  How do we even know what species are in there?  And can you blame your stinky farts on your gut bacteria?

 

 

023 Mergers and Aquisitions

In this episode from our centenary series exploring 100 ideas in genetics, we’re looking at mergers and acquisitions – but in a biological rather than a financial sense.  We find out what happens when two cells decide to move in together, unpack the history of genetic engineering and bleat on about the story of Dolly the Sheep.

 

 

 

022 Big Questions about the Big C

In this episode we’re digging into some of the mysteries around what’s often seen as the ultimate genetic disease, finding out how low doses of radiation might affect cancer risk and why tumours start in some tissues and not others.

 

 

 

021 In case you missed it…

In this episode we’re bringing you a selection of our favourite bits from the year so far that you might have missed.  We’re taking a short summer break and will be back again with new episodes from the 12th of September. In the meantime, I’ve picked a few highlights from our earlier episodes that you may have missed. I hope you enjoy listening to them, whether again or for the first time, as much as producer Hannah and I enjoyed making them.

 

 

020 Age, Sex and Death

In this episode from our centenary series exploring 100 ideas in genetics, we’re telling tales of sex and death, and exploring the very darkest side of genetics.

 

 

 

 

019 The Genetic Time-machine

In this episode from our centenary series exploring 100 ideas in genetics, we’re telling tales of sex and death, and exploring the very darkest side of genetics.

 

 

 

 

018 Cut. Paste. Copy. Repeat.

In this episode from our centenary series covering 100 ideas in genetics, we’re exploring the dark heart of the genome, untying nature’s shoelaces, and looking back at the discovery of RNA splicing.

 

 

 

 

017 Happy 100th Birthday to Us

In this episode we’re celebrating the actual birthday of the society – founded on the 25th June, 100 years ago – with past president, Nobel laureate and winner of the Genetics Society’s first centenary medal, Sir Paul Nurse.

 

 

 

 

016 Genetics by Numbers

In this episode from our centenary series exploring 100 ideas in genetics, we’re unravelling the story of the double helix, cracking the triplet code, and sketching out a Punnett square.

 

 

 

 

015 Up the Garden path

In this episode we’re diving into the valley of hybridisation, visiting the Society’s medal-winning Mendel-based garden at the RHS Chelsea Flower Show. Plus, the importance of playing with your genes.

 

 

 

 

014 The Seeds of a great Idea

In this episode from our series exploring 100 ideas in genetics, we’re taking the train to London with William Bateson, seeking the secrets of snapdragons, and unravelling the next generation of DNA sequencing technology.

 

 

 

 

 

013 The Zero Dollar Genome

Dr. Kat Arney talks to George Church about his plans for the ‘Zero Dollar Genome’, and finds out how one scientist’s interest in personal genomics got a little too close to home.

 

 

 

012 Strands of Life

In this episode from our series exploring 100 ideas in genetics, we explore the discovery of chromosomes – the strands of genetic material within every living cell – take a look at Lyonisation, and solve the case of the missing chromosomes.

 

 

 

011 Darwin Vs. Mendel

What would have happened if Darwin had read Mendel?  And what if they’d been on Twitter?  Plus, something else that Darwin would have loved – an ambitious project to sequence the DNA of everything across the tree of life.

 

 

 

 

010 Not “just the wife” – the overlooked stories of women in genetics

In every other episode of Genetics Unzipped, we’re celebrating the Genetics Society’s centenary year by exploring some of the top 100 ideas in genetics. This time it’s the stories of four women who have often been overlooked in the history of 20th century genetics: Esther Lederberg, Harriet Creighton, Tsuneko Okazaki and Martha Chase.

 

 

009_Chimps, cancer genes and missing kids

In this episode we bring you a very special interview with Mary-Claire King – one of the world’s leading geneticists, whose work has spanned everything from comparing chimps and humans to finding the first breast cancer gene to reuniting families that have been torn apart.

 

 

 

008_Getting ready for genomic medicine

This special episode is brought to you in association with the Genomics Education programme – part of Health Education England.  We’ll be finding out how genomic medicine is coming into the NHS, and what it means for everyone working in the health service.

 

 

 

007_Supermodels of science

In this episode from our series exploring 100 ideas in genetics, we’re entering the glamorous world of modelling, meeting the supermodels… of science. We’re taking a look at some of the field’s top models – the eclectic collection of organisms that have been put to work in the lab to reveal the secrets of biology.

 

 

 

006_Big fat failure

In this episode we’re looking at the genetics of failure – we talk to Dr Giles Yeo about why we fail to lose weight thanks to our genes, and why ignoring genetic information and DNA diversity leads to billions of dollars being wasted on drugs that don’t work.

 

 

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